Manchester City were unable to convert dominance into goals as they were held to a goalless draw with Southampton.
The home side controlled possession in the first half and came closest to scoring through Ilkay Gundogan and Raheem Sterling.
Southampton were awarded a penalty on 61 minutes when Kyle Walker fouled Adam Armstrong, for which he was shown a red card.
However, both decisions were overturned after referee Jonathan Moss reviewed on the pitch-side monitor.
Sterling fired home at the other end late on, but his strike was ruled out for offside.
A first draw of the season for Man City puts them second on 10 points, while Southampton drop to 15th with four points.