Substitute Odsonne Edouard scored twice and Wilfried Zaha converted a penalty as Crystal Palace beat 10-man Tottenham Hotspur for their first victory under new manager Patrick Vieira.
Spurs, who were missing Son Heung-min through injury, suffered another setback when Eric Dier went off with an early injury.
After a combative but goalless first half, Spurs lost Japhet Tanganga to a red card for two bookings in quick succession before the hour.
Palace took advantage with a penalty on 76 minutes for a handball by Ben Davies that Zaha converted. It was the first goal conceded by Spurs this season.
Zaha then teed up Edouard to score 28 seconds after coming on for his debut.
And the Frenchman struck again in stoppage time from Conor Gallagher’s assist to seal a comfortable win.
Spurs stay top despite dropping their first points of the season, while Palace move up to 11th with five points.