Manchester United must get at least a draw against Liverpool to keep the title race alive.
If they suffer a home defeat, their local rivals Manchester City will be crowned champions.
Manchester United have reported no new injuries for the visit of Liverpool. Anthony Martial and Phil Jones are long-term absentees.
Jurgen Klopp has reported no fresh injuries, but remains without Virgil van Dijk, Jordan Henderson, Joel Matip and Joe Gomez who are all working their way back to full fitness.
Did you know?
Manchester United have lost just one of their last 15 home matches against Liverpool in all competitions (W10 D4), and are unbeaten in their last eight, since March 2014.
Marcus Rashford has been directly involved in five goals in his last four home matches against Liverpool in all competitions, scoring four and assisting one.
Liverpool have lost just one of their last nine Premier League matches against Man Utd.
Jurgen Klopp is looking for his first win at Old Trafford, at the seventh attempt (D4 L2). He has managed away at Man Utd without ever winning more times than against any other opponent in his managerial career.
Referee: Michael Oliver. Assistants: Stuart Burt, Simon Bennett. Fourth official: Craig Pawson. VAR: Paul Tierney. Assistant VAR: Timothy Wood.