Second-placed Liverpool must beat Wolverhampton Wanderers and hope that Manchester City either draw or lose against Aston Villa.
The Reds have won each of their last 10 Premier League matches against Wolves, including eight clean sheets, since a 1-0 home loss in December 2010 under Roy Hodgson.
The Reds are unbeaten in their last 22 Premier League home matches (W17 D5), scoring 53 goals and conceding just 10. If they avoid defeat here, it will be the fifth time they have gone through an entire Premier League campaign without losing at home, the joint-most of any team (Chelsea have done so five times).
Sadio Mane has scored six goals on the final day of the Premier League. Only Harry Kane (eight) has netted more among players currently playing in the division.
Wolves have only scored 37 Premier League goals this season but could finish in the top eight in the division. Only two sides have scored fewer than 40 Premier League goals in a season but finished in the top eight: Fulham in 2008/09 (scored 39, finished seventh) and Burnley in 2017/18 (36, finished seventh).
Referee: Anthony Taylor. Assistants: Gary Beswick, Adam Nunn. Fourth official: Tony Harrington. VAR: Stuart Attwell. Assistant VAR: Dan Cook.