Brentford can be only the third team to win at the reigning champions in their debut Premier League season (excluding 1992/93), after Derby County in 1996/97 and AFC Bournemouth in 2015/16.
Kevin De Bruyne has been involved in 13 goals in his last 12 appearances against promoted sides, with five goals and eight assists.
Manchester City have won each of their last 17 Premier League matches played on Wednesdays, including a 1-0 win against Brentford in the reverse fixture in December. In Premier League history, only Liverpool have had a longer winning run on a specific day of the week (21 on Saturday between 2018 and 2020).
Ivan Toney has scored six Premier League goals this season, twice as many as any other Brentford player. He could become the first player to score in three consecutive top-flight matches for the Bees since Len Townsend in 1946.
Match officials
Referee: Darren England. Assistants: Simon Long, Timothy Wood. Fourth official: Andy Madley. VAR: Jonathan Moss. Assistant VAR: Neil Davies
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